4. Generally speaking, ______ according to the directions, the drug has no side effect.
A. When taking B. when taken C. when to take D. when to be taken
5. The research is so designed that once ______ nothing can be done to change it.
A. begins B. begun C. beginning D. having begun
6. _____ in 1613, Harvard is one of the most famous universities in the United Stated.
A. being founded B. Founded C. It was founded D. Founding
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